Active Pharmaceutical Ingredients of Interest

CARIPRAZINE

Chemical Name N’-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea
CAS Number 839712-12-8
Therap. Category Antipsychotic
Molecular Formula
C21H32Cl2N4O
Molecular Weight
427.41

BREXPIPRAZOLE

Chemical Name 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]quinolin-2(1H)-one
CAS Number 913611-97-9
Therap. Category Antiphychotic
Molecular Formula
C25H27N3O2S
Molecular Weight
433.57

CABERGOLINE

Chemical Name 1-[(6-Allylergolin-8-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
CAS Number 81409-90-7
Therap. Category To treat Hyperprolactinemia
Molecular Formula C26H37N5O2
Molecular Weight 451.615

EMPAGLIFLOZIN

Chemical Name (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol
CAS Number 864070-44-0
Therap. Category Antidiabetic
Molecular Formaula C23H27ClO7
Molecular Weight 450.91

LINAGLIPTIN

Chemical Name 8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
CAS Number 668270-12-0
Therap. Category Antidiabetic
Molecular Formula C25H28N8O2
Molecular Weight 472.553

VILDAGLIPTIN

Chemical Name (2S)-1-[2-[(3-hydroxy-1-adamantyl)
amino]acetyl]pyrrolidine-2-carbonitrile
CAS Number 274901-16-5
Therap. Category Antidiabetic
Molecular Formula C17H25N3O2
Molecular Weight 303.406

TENELIGLIPTIN

Chemical Name {(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-
piperazinyl]-2-pyrrolidinyl}(1,3-thiazolidin-3-
yl)methanone
CAS Number 760937-92-6
Therap. Category Antidiabetic
Molecular Formula C22H30N6OS
Molecular Weight 426.58

MIRABEGRON

Chemical Name  2-(2-Amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)
phenyl]acetamidephenyl]acetamide
CAS Number 223673-61-8
Therap. Category To treat Overactive bladder
Molecular Formula C21H24N4O2S
Molecular Weight 396.51

VORTIOXETINE

Chemical Name 1-{2-[(2,4-Dimethylphenyl)sulfanyl]
phenyl}piperazine
CAS Number 508233-74-7
Therap. Category Antidepressant
Molecular Formula C18H22N2S
Molecular Weight 298.45

TAVABOROLE

Chemical Name 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
CAS Number 174671-46-6
Therap. Category Antifungal
Molecular Formula C7H6BFO2
Molecular Weight 151.93

OXCARBAZEPINE

Chemical Name 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide
CAS Number 28721-07-5
Therap. Category Anticonvulsant
Molecular Formula C15H12N2O2
Molecular Weight 252.268

ESLICARBAZEPINE

Chemical Name (9S)-9-hydroxy-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene-2-carboxamide
CAS Number 236395-14-5
Therap. Category Anticonvulsant
Molecular Formula C17H16N2O3
Molecular Weight 296.326

CLOMIPRAMINE

Chemical Name ( 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
CAS Number 303-49-1
Therap. Category Antidepressant
Molecular Formula C19H23ClN2
Molecular Weight 314.852

RIMEGEPANT

Chemical Name [(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
CAS Number 1289023-67-1
Therap. Category Antimigraine
Molecular Formula C28H28F2N6O3
Molecular Weight 534.568

ATOGEPANT

Chemical Name (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one.
CAS Number 1374248-81-3
Therap. Category Antimigraine
Molecular Formula C29H23F6N5O3
Molecular Weight 603.528

SODIUM NITROPRUSSIDE

Chemical Name Disodium pentacyanonitrosylferrate(2-) dihydrate
CAS Number 13755-38-9
Therap. Category To lower blood pressure
Molecular Formula C5FeN6Na2O
Molecular Weight 261.921

ACTIVE PHARMACEUTICAL INTERMEDIATES OF INTEREST

Chemical Name 2-(Chloromethyl)-4-methylquinazoline
CAS Number 109113-72-6
Therap. Category Intermediate for Linagliptin
Molecular Formula C10H9ClN2
Molecular Weight Intermediate for Linagliptin
Chemical Name 1-(3-methyl-1-phenyl-1H-pyrazol-4-yl)piperazine
CAS Number 401566-79-8
Therap. Category Intermediate for Teneligliptin
Molecular Formula C₁₄H₁₈N₄
Molecular Weight 242.32
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